Services
EnquBio's Comprehensive Drug Discovery Solutions & Services
At EnquBio, our expert team delivers high quality, efficient, and dependable R&D solutions that enable pharmaceutical and biotech partners to advance and expand their drug development pipelines.
- Discovery Biology
- Plate-Based Pharmacology
- Immunology
- Ex Vivo Pharmacology
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In Vivo Pharmacology
- Inflammation & Autoimmune Diseases Models
- Syngeneic and Cell Line-Derived Xenograft (CDX) Models
- Humanized Immuno-Oncology Models
- FLI and BLI based optical in vivo imaging for orthotopic models and drug biodistribution
- Pharmacokinetic and Pharmacodynamic (PK/PD)
- Non-GLP Toxicology
- Other In Vivo Efficacy Models
- Biomarker & Bioanalysis
Tissue-Based Ex Vivo & Primary Cell Models
EnquBio supports customized tissue processing, primary-cell isolation, short-term culture and ex vivo pharmacology workflows for selected tissues. Study designs are tailored to tissue source, cell viability, target biology, assay feasibility and the biological question being addressed.
Tissue- and Primary-Cell Models for Translational Pharmacology
Fresh tissues can be processed into fit-for-purpose primary-cell or short-term ex vivo systems to interrogate tissue-specific biology.
Start with biologically relevant material
Use freshly collected animal or human tissue where appropriate to preserve disease- or organ-relevant biology.
Isolate relevant cell populations
Generate primary-cell preparations for controlled functional and pharmacodynamic studies.
Build around the biological question
Select processing, culture and endpoints based on tissue source, viability, target biology and study objective.
Representative Tissue Systems
Available models are selected project by project based on tissue source and feasibility.
CNS / Brain-Derived
- Microglia
- Neuron-related preparations
- Brain-derived primary cells
- Inflammatory / signaling readouts
Immune Tissues
- Spleen
- Splenocytes
- Lymphoid populations
- Ex vivo stimulation assays
Liver-Derived
- Hepatocyte-related workflows
- Liver-derived cell preparations
- Target / pathway endpoints
- Functional response
Other Project-Specific Tissues
- Fresh tissue processing
- Primary-cell isolation
- Short-term culture
- Customized readouts
Typical Workflow
Tissue Collection
Fresh tissue collected or received under defined conditions.
Processing
Mechanical / enzymatic dissociation or other fit-for-purpose preparation.
Cell Enrichment
Enrich relevant primary-cell populations where required.
Ex Vivo Treatment
Compound exposure, stimulation or mechanistic challenge.
Endpoint Analysis
Functional, cellular, protein and molecular readouts.
Integrated Readouts
Have a tissue-specific pharmacology question?
Tell us the tissue source, target biology, available material and desired readouts. We can evaluate feasibility and build a fit-for-purpose ex vivo workflow.
Contact Our Scientists →