Services
EnquBio's Comprehensive Drug Discovery Solutions & Services
At EnquBio, our expert team delivers high quality, efficient, and dependable R&D solutions that enable pharmaceutical and biotech partners to advance and expand their drug development pipelines.
- Discovery Biology
- Plate-Based Pharmacology
- Immunology
- Ex Vivo Pharmacology
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In Vivo Pharmacology
- Inflammation & Autoimmune Diseases Models
- Syngeneic and Cell Line-Derived Xenograft (CDX) Models
- Humanized Immuno-Oncology Models
- FLI and BLI based optical in vivo imaging for orthotopic models and drug biodistribution
- Pharmacokinetic and Pharmacodynamic (PK/PD)
- Non-GLP Toxicology
- Other In Vivo Efficacy Models
- Biomarker & Bioanalysis
Integrated In Vivo–Ex Vivo Biomarker & PK/PD Analysis
EnquBio integrates in vivo pharmacology with coordinated analysis of blood, plasma, tumor and tissue samples to build mechanistic PK/PD relationships across multiple biological levels. Programs can combine PK with cellular, protein, soluble and molecular biomarker endpoints.
Build a Mechanistic PK/PD Story Across Biological Levels
Integrate drug exposure with target engagement, pathway modulation, cellular response, biomarkers and efficacy within the same program.
Connect PK with downstream biology
Interpret biomarker and pharmacodynamic changes in the context of measured drug exposure.
Follow the pathway from target to response
Combine target engagement, signaling and cell-level endpoints to support mechanism-of-action interpretation.
Bring in vivo and bioanalysis together
Analyze blood and tissues from in vivo studies using coordinated multi-platform workflows.
Exposure → Target → Pathway → Cell → Biomarker → Response
Representative Biomarker Modalities
Target Engagement
- Receptor occupancy
- Target expression
- Protein degradation
- Binding-related PD
Pathway Signaling
- Phosphoproteins
- Protein expression
- Gene expression
- Mechanistic PD markers
Cellular Pharmacodynamics
- Immune-cell profiling
- Activation / differentiation
- Cellular target expression
- Functional state
Soluble Biomarkers
- Cytokines
- Chemokines
- Circulating PD markers
- Tissue biomarkers
Typical Program Workflow
In Vivo Study
Dose, efficacy and scheduled biosampling.
Sample Collection
Blood, plasma, tumor and tissue at defined time points.
Multi-Platform Analysis
Flow, MSD, Jess/Western, qPCR/ddPCR and PK.
Data Integration
Align exposure with target, pathway and biomarker response.
Mechanistic Interpretation
Build a coherent PK/PD and efficacy story.
Building a mechanistic PK/PD strategy?
Share your in vivo model, dosing design, target biology and available samples. Our scientists can help prioritize the biomarkers that best connect exposure with mechanism and response.
Contact Our Scientists →